Matrix type transdermal films of Metoprlol Succinate, an antihypertensive drug were prepared using different polymers such as Ethyl Cellulose, HydroxyPropyl Methyl Cellulose (E15, E50) and Polyvinyl pyrrolidone in varied ratios. The present study aims to formulate and evaluate transdermal film for Metoprlol Succinate,The purpose of this research work was to develop and evaluate matrix-type transdermal therapeutic system of Metoprlol Succinate containing different ratios of hydrophilic and hydrophobic polymeric combinations. The formulations were prepared by using solvent casting technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. All formulations carried dimethyl sulfoxide (5%) as penetration enhancer and propylene glycol (30%) as plasticizer in chloroform and ethanol as solvent system. The diffusion studies were performed by using Franz diffusion cells. The formulation J with combination of polymers (HPMC E50+EC) emerged to be ideal formulation. The developed transdermal film increases the efficacy for the therapy of hypertension. Physicochemical parameters were characterized. The permeability studies indicate that the drug is suitable for transdermal drug delivery. The film were evaluated for various parameters like Thickness, Water-Vapour Permeability, Tensile Strength, moisture loss, moisture uptake, folding endurance, Drug Content, flatness, surface pH, swellability, % elongation, skin irritation study and Diffusion studies. The Optimized formulation containing HPMC E50+EC (3:2), with enhancer DMSO showed 70% drug release after 12 hours.
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